UC San Diego Today

A new tool could make it easier to study scarce and mysterious plant molecules. Researchers co-led by the University of California San Diego have developed so-called microbial cell factories—using E. coli and yeast—to produce a special class of plant hormones, known as strigolactones, at unprecedented levels. By amplifying production of strigolactones, which occur in such low amounts in plants, researchers now have the ability to study these elusive plant molecules in much greater depth than before. The work could help improve sustainable agricultural practices by offering deeper insights into how plants make and use their natural hormones to adapt and survive.

Scientists led by UC San Diego have developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more. By knocking out a gene circuit responsible for producing lactic acid—a metabolite that makes the cells’ environment toxic—researchers eliminate a primary hurdle in developing cells that can produce higher amounts of pharmaceuticals like Herceptin and Rituximab, without compromising their growth or energy production.

UC San Diego Assistant Professors Itay Budin and Christopher Obara have been named Allen Distinguished Investigators by the Paul G. Allen Family Foundation. The pair will receive $1.5 million over three years to develop visualization and tracking techniques to observe key cellular functions in unprecedented detail.

New research led by UC San Diego’s Scripps Institution of Oceanography highlights the critical role of mangroves in protecting coastal communities from the devastating effects of climate change—particularly hurricanes.